![]() ![]() The focus of the DHART SPORE is on tumors that develop in patients with neurofibromatosis type 1 (NF1). The DHART SPORE represents the translational research component of the Cancer Center’s Pediatric Malignancies Program, which brings together basic and clinical researchers with the shared goal of improving the outcome for children with cancer. Across all four projects, genome-wide analysis of clinical specimens and murine cancers will elucidate molecular mechanisms of tumorigenesis in primary and second malignancies. This program encompasses four highly integrated projects and three cores. Instead, the strategy is to implement new treatments for tumors that develop in different tissues due to NF1 mutations. In contrast to most other SPORE efforts supported by the NCI, the DHART SPORE does not focus on a particular type of cancer. The collaborating researchers are pursuing this goal by conducting integrated, mechanistically based translational research. The overall goal of the SPORE is to implement effective new targeted treatments for tumors characterized by mutations of the NF1 tumor suppressor gene. Other UCSF investigators conducting research on the SPORE are Mignon Loh, MD Benjamin Braun, MD, PhD Ellion Stieglitz, MD Jean Nakamura, MD Andrew E. ![]() Wade Clapp, MD (Indiana University School of Medicine), and brings together researchers at the Pediatric Branch of the NCI and eight academic institutions. The Developmental and HyperActive Ras Tumor (DHART) SPORE is sponsored by the National Cancer Institute, with the goal of improving diagnosis, prognostication, and therapy of brain tumors. NCI Specialized Program Of Research Excellence (SPORE) ![]()
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